Model library for bioprocess in BioVL

Choose the microorganism to simulate

Monod Herbert Fermentation (Aerobic / Anaerobic)

The Monod equation is a mathematical empirical equation for the growth of microorganisms. It is like a building block of microbial growth.

It is used to describe multiple microorganisms species, changing the maximum specific growth rate of the microorganisms and affinity constant for substrate uptake.

Furthermore, the other rates are calculated through the yields.

  

It is possible to transform the system to anaerobic, if kla is 0 or initial concentration of oxygen 0. However, a aerobic system will have a higher yield of substrate-biomass.

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Saccharomyces cerevisiae (Aerobic)

This is the microorganisms in charge of beer, wine and yeast production.

Maybe one of the most appreciated microorganisms in the universe.

This beautiful yeast has a unique physiology and it is one of the most used biological systems as host for genetic manipulations (among with Escherichia coli). Also, it has a long history of safety use and consumption, and lack of production of toxins, so therefore, most strains of S.cerevisiae are considered as safe (GRAS).

In the industry, it is highly appreciated due to its ability of growth under aerobic and anaerobic conditions. Saccharomyces cerevisiae is used for the production of yeast or ethanol.

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Escherichia coli (Aerobic)

E.coli is an important bacteria in biotechnology as it can be grown and cultured easily and inexpensively in a laboratory setting, and has been intensively investigated for over 60 years.

Naturally, E.coli produces acetate and biomass following a similar pathway than S.cerevisiae.

However, this microorganism is wildly used in genetic modification.

Not ready yet. However, E.coli has the same Crabtree Effect than the S.cerevisiae (the difference is that instead of ethanol, we have acetate in E.coli)

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Mannheimia succiniciproducens (Anaerobic)

One of the microorganisms that it is used in the production of succinic acid in large scale.

Succinic acid is a building block in the agricultural, food and pharmaceutical industries. Moreover, succinate has been place in the top 12 pf platform chemicals from biomass, with a global production estimated at 16,000 to 30,000 tons a year and an annual growth rate of 10%.

It is the precursor to some polyesters and biodegradable polymers. Furthermore, succinic acid is also an important safe food addictive as an acidity regulator; use also in pharmaceutical products as intermediate.

Historically, succinic acid was obtained from amber by distillation and has thus been know as "spirit of amber". It is a great example of the transition from a chemical to a biochemical production

Not ready yet
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Corynebacterium glutamicum (Aerobic)

In this bioconversion, the bacteria is producing L-Glutamic acid. L-Glutamic acid is commercially one of the most important amino acids, Glutamic acid is produced on the largest scale of any amino acid, with an estimated annual production of about 1.5 million tons in 2006.

(Again) The chemical synthesis was supplanted by this aerobic fermentation , being this one the most widely used in production.

Not ready yet.
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